Not really... Not in how Obama is using his cabinets and advisors. I worked for HHS... It, like most departements, runs it self... the Secretaries set policy, but the nuts and bolts are run by the entrenched gov lifers in place now.
Obama is using the secretaries whose departments fall under important legislation he wants to pass as lobbyists. Its one of the reason so many house and senators were vetted in key departments as well as why Rahm emanuel is chief of staff.
Me... I have no legal training, but I'd consistently tell Scalia, Roberts, Alito and Thomas to go Fuck themselves and would be a reliable progressive vote... until they impeach me, it would be a fun show!
I'm not sure Gregg is gonna care about his party... He's getting older, he faces a potentially tough re-election against Paul Hodes in an increasingly Blue area of the country and is in the minority party... Not a recipe for fun.
With this move, he runs Sec of commerce for a few years, leaves and gets big money on the speaker circuit witht he bipartisan tab or takes a few nice cushy board member jobs. THis helps his Bi Partisan cred which many eat up and will help him post politics.